![]() ![]() In order to act like GABA itself, the medication would have to be highly dosed, but even lower doses are sufficient to increase the effect of endogenous GABA two to threefold. depression, dizziness, hypotension, muscle weakness and impaired coordination.ĭrugs enhance the effect of the neurotransmitter GABAīenzodiazepines, barbiturates and anaesthetics such as propofol act via specific adhesion sites on receptors that lie at contact points of nerve cells (synapses) in the brain and increase the effect of the inhibiting endogenous neurotransmitter GABA (gamma-aminobutyric acid). However, benzodiazepines are not only potentially addictive, but can also cause serious side effects, e.g. In the course of a year, about 20 percent of all Germans take such drugs or are treated with them for anaesthetic purposes. The classes of substances that exert a calming effect include alcohol, barbiturates, opiates, and since the 1950s, the benzodiazepines, which are now among the world's most widely prescribed drugs. ![]() The difference between calming and hypnotic effect depends solely on the dosage. Sedatives, sleeping pills and relaxants are the most frequently prescribed psychotropic drugs. They report in the current issue of the Journal of Biological Chemistry (online).Įvery fifth German takes a sedative once a year The researchers have now been granted a patent for their discovery. They soothe, relieve anxiety and promote sleep. Hanns Hatt have discovered that the two fragrances Vertacetal-coeur (VC) and the chemical variation (PI24513) have the same molecular mechanism of action and are as strong as the commonly prescribed barbiturates or propofol. Helmut Hass from the Heinrich Heine University in Düsseldorf, researchers from Bochum led by Prof. ![]()
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